GLP-1 Meds Slowed Your Digestion? This Can Help.
Semaglutide constipation, tirzepatide constipation, GLP-1 constipation relief—if you’re searching these terms, you’re already feeling the digestive slowdown that often comes with GLP‑1 medications. These powerful medications can help reshape metabolic health, but they can also leave you backed‑up, bloated, and uncomfortable.
The good news? You don’t have to choose between better blood‑sugar control and regular bowel movements. Below, we explain exactly why GLP‑1 constipation happens, recommended ways to get relief, and our newest supplement for GLP‑1‑induced constipation—Motility by Strive.
Think sluggish transit time, hard stools, and that “full‑to‑your‑eyeballs” feeling after just a couple bites. It’s frustrating when everything else is trending healthier. But with the right strategy, you can keep your gut moving while you keep the weight off.
Let’s dig into the science—then the solution.
GLP‑1 Constipation: Why Semaglutide & Tirzepatide Slow Digestion
How GLP‑1 Receptor Agonists Delay Gastric Emptying
GLP-1 receptor agonists work by mimicking a natural hormone that helps regulate insulin, appetite, and stomach emptying. That last part is key: slowed gastric emptying is part of how these medications make you feel fuller longer.1
Key Symptoms: Bloating, Fullness, & Slow Transit Time
But here’s the thing, what’s helpful for weight loss can also make digestion feel... stuck.
Your food hangs out in your stomach longer. Bowel movements take their sweet time. You might start feeling like a human traffic jam. Backed up, bloated, and wondering if this is just the tradeoff for better metabolic health.
Spoiler: it doesn’t have to be.
GLP-1 therapy is worth sticking with. But your gut needs some backup. That’s where Motility steps in.
Supportive Relief for Semaglutide or Tirzepatide Constipation
Lifestyle Wins: Hydration, Fiber, & Gentle Movement
Before reaching for any supplement, dial in the basics: drink enough water, add soluble fiber slowly, and get light activity after meals to encourage motility.
Targeted Supplements That Speed Up Motility
Magnesium, ginger, and 5‑HTP have published research showing healthier transit times—which brings us to Motility.
Motility by Strive: Comprehensive Supplement for GLP‑1‑Induced Constipation
Motility is formulated to meet the demands of GLP-1 users looking for real relief.
We talked to patients. We dug into science. And then we formulated something that isn’t just supportive—it’s strategic.
Motility is:
- Non-habit forming
- Functional (not just symptomatic)
- Gut-brain connected
- Gentle enough to use daily
No brute force. Just targeted support that helps your system get back into rhythm.
4 Science‑Backed Ingredients That Restore Gut Rhythm
Let’s break it down:
1. Ginger
Ginger is a gut hero. It helps stimulate gastric emptying, balances gut movement, and even modulates 5-HT3 receptors—those little players involved in nausea and gut-brain communication. Perfect for that post-semaglutide sluggishness. It’s anti-inflammatory, anti-nausea, and anti-”I feel like I swallowed a rock.”2
2. Magnesium Citrate
Unlike harsher laxatives, magnesium citrate supports peristalsis—the natural wave-like contractions of your intestines. It helps relax and contract muscles in the GI tract, keeping things moving without the cramping or urgency. Think: progress, not panic.3
3. 5-HTP
Serotonin isn’t just for your brain. About 90% of your body’s serotonin lives in your gut. 5-HTP, a precursor to serotonin, supports enteric nervous system function. Translation? It helps your gut remember how to coordinate movement and function like a team player again.4
4. Artichoke Extract
Bile flow matters. Artichoke supports digestion by helping to stimulate bile production, which helps break down fats and reduce bloating. It’s also rich in antioxidants for extra gut support. Bonus: It’s like giving your liver a little high-five.5
Non‑Habit‑Forming Support vs. Traditional Laxatives
Laxatives work by forcing your body to purge. They might help in a pinch, but long-term? They can create dependency, discomfort, and a gut that forgets how to do its job.
Motility isn’t about forcing your body. It’s about working with it.
By enhancing your nervous system’s natural rhythms and restoring healthy movement, this supplement offers sustainable support—especially valuable if you’re in it for the long game with GLP-1 therapy.
Because sustainable > sporadic.
Gut‑Brain Axis 101: Serotonin, 5‑HTP & Digestive Signaling
Why 90 % of Serotonin Lives in Your Gut
GLP-1s affect more than your gut. They also influence signaling between your brain and digestive system. That’s why Motility includes ingredients that support neurotransmitters and nervous system communication.
We like to think of it as giving your gut its rhythm back. And that rhythm? It starts with serotonin, magnesium, and movement.
There’s a reason some call the gut the “second brain.” It talks to your nervous system, your hormones, even your emotions.6 When your gut’s out of sync, it can throw everything off. But when it’s in rhythm? That’s when the magic happens.
How to Dose Motility for Optimal GLP‑1 Success
Daily Schedule: Timing Capsules Around Your Injection
Motility is designed to be flexible for your lifestyle. The suggested dose is 1 capsule, up to 3 times daily, with or without food. Most people start with 1 capsule a day and increase as needed.
Because it’s non-stimulant and non-habit forming, you can take it daily or as support when digestion feels a little off.
It’s there when you need it. And quiet when you don’t.
FAQ: GLP‑1 Side‑Effect Troubleshooting
How Long Does GLP-1 Induced Constipation Usually Last?
Many patients notice the slowdown in the first 2–4 weeks; symptoms often improve with lifestyle tweaks and Motility.
Is Motility OK to Take Every Day?
Yes—its non‑stimulant, non‑habit‑forming formula is gentle enough for daily support.
Before starting any over-the-counter (OTC) medications, please consult with your healthcare provider. Certain medications may interact with your current prescription medications, medical conditions, or other supplements. Your healthcare provider can provide guidance tailored to your specific health needs.
How soon will I see digestive improvements from Motility?
- Many users experience relief within the first few days, with continued improvement over weeks.
Who It’s For
- You’re on semaglutide, tirzepatide, or other GLP-1 meds and want smoother digestion
- You deal with chronic constipation but want a gentler, long-term option
- You’re bloated, irregular, or uncomfortable and need support that doesn’t throw your system into chaos
- You’re curious about supplements that support the gut-brain axis
- You’re done pretending that “just deal with it” is a sustainable plan
Motility x You: A Smarter Way to Support GLP-1 Success
When digestion flows, progress follows. Motility helps you stay regular without pausing your GLP‑1 therapy—so every weigh‑in, workout, and blood‑sugar check keeps trending the right way.
Ready to feel lighter and bloat‑free?
- Order Motility Today (tap here)
- Take 1 capsule with tonight’s evening meal. Most users notice easier, more predictable bowel movements within the first week.
- Track your wins. Less bloating, smoother energy, and zero “backed‑up” days—guaranteed or your money back.
Get your gut moving so you can keep moving toward your goals.
References
- Drucker DJ. Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Cell Metab. 2018 Apr 3;27(4):740-756. doi: 10.1016/j.cmet.2018.03.001. PMID: 29617641.
- Hu ML, Rayner CK, Wu KL, Chuah SK, Tai WC, Chou YP, Chiu YC, Chiu KW, Hu TH. Effect of ginger on gastric motility and symptoms of functional dyspepsia. World J Gastroenterol. 2011 Jan 7;17(1):105-10. doi: 10.3748/wjg.v17.i1.105. PMID: 21218090; PMCID: PMC3016669.
- National Institutes of Health Office of Dietary Supplements. Magnesium Fact Sheet for Health Professionals.
- Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 2007 Jan;132(1):397-414. doi: 10.1053/j.gastro.2006.11.002. PMID: 17241888.
- Amini MR, Sheikhhossein F, Talebyan A, Bazshahi E, Djafari F, Hekmatdoost A. Effects of Artichoke Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Clin Nutr Res. 2022 Jul 25;11(3):228-239. doi: 10.7762/cnr.2022.11.3.228. PMID: 35949559; PMCID: PMC9348909.
- Mawe GM, Hoffman JM. Serotonin signalling in the gut--functions, dysfunctions and therapeutic targets. Nat Rev Gastroenterol Hepatol. 2013 Aug;10(8):473-86. doi: 10.1038/nrgastro.2013.105. Epub 2013 Jun 25. Erratum in: Nat Rev Gastroenterol Hepatol. 2013 Oct;10(10):564. PMID: 23797870; PMCID: PMC4048923.
