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Vasoactive Intestinal Peptide (VIP)
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Vasoactive Intestinal Peptide (VIP) is a naturally occurring 28 amino acid peptide renowned for its broad physiological roles such as vasodilation, anti-inflammatory activities, and the regulation of endocrine and exocrine systems. It is primarily used to manage Chronic Inflammatory Response Syndrome.
ACTIVE INGREDIENTS
Vasoactive Intestinal Peptide
A peptide that is present in various tissues, including the gut, pancreas, central nervous system, and peripheral nervous system.
HOW TO USE
Suggested use
Administer 1 spray (50 mcg) four times daily alternating nostrils for the first month. May increase to 2 sprays (100 mcg) four times daily alternating nostrils for the second month.
DISCLAIMER
This compounded medication is only available when the commercially available product is unavailable or when a prescriber determines that there is a clinically significant difference for the patient.
Medicine Information
Potential Benefits
- Help regulate inflammatory and autoimmune disorders by suppressing pro-inflammatory factors
- Supports nerve regeneration in grey matter nuclear atrophy (as seen in CIRS)
- Enhances airway relaxation and oxygenation
- Normalizes intestinal motility and secretions; potentially alleviate gastroparesis
- Normalize estrogen and testosterone levels
- Transiently improves insulin sensitivity and stimulates glucose-dependent insulin secretion
- Promotes proliferation of pancreatic islet β-cells
Treament Protocol
Legal
Storage Instructions
Warnings
Possible Side Effects
- Headache, dizziness, stomach discomfort, and flushing
- Hypotension
Manufacturer Info
How It Works
Vasoactive intestinal peptide (VIP) mediates its effects primarily through VPAC1 and VPAC2 receptors, which belong to the class B G protein-coupled receptor (GPCR) family. VIP initiates an enzymatic cascade leading to the activation of cAMP Response Element-Binding protein (CREB), influencing gene expression and various cellular responses. The activation of these pathways leads to smooth muscle relaxation, neuroprotection, vasodilation, enhanced glucose-dependent insulin secretion, reduced pro-inflammatory cytokines , and increased anti-inflammatory cytokines.
F.A.Q
References
Shoemaker RC, Katz D, Ackerley M, et al. Intranasal VIP safely restores volume to multiple grey matter nuclei in patients with CIRS. Internal Medicine Review 3 (2017): Issue 4. pg 1-14.
Hou X, Yang D, Yang G, Li M, Zhang J, Zhang J, Zhang Y, Liu Y. Therapeutic potential of vasoactive intestinal peptide and its receptor VPAC2 in type 2 diabetes. Front Endocrinol (Lausanne). 2022 Sep 20;13:984198. doi: 10.3389/fendo.2022.984198. PMID: 36204104; PMCID: PMC9531956.
Vu JP, Larauche M, Flores M, Luong L, Norris J, Oh S, Liang LJ, Waschek J, Pisegna JR, Germano PM. Regulation of Appetite, Body Composition, and Metabolic Hormones by Vasoactive Intestinal Polypeptide (VIP). J Mol Neurosci. 2015 Jun;56(2):377-87. doi: 10.1007/s12031-015-0556-z. Epub 2015 Apr 23. PMID: 25904310; PMCID: PMC4458420.
