The image shown is for illustrative purposes only and does not represent the actual appearance of your specific compounded medication.

No items found.
No items found.

Weight Management

Injection

RX ONLY

Semaglutide/Glycine/B12

*
  • ACTIVE INGREDIENTS

    Semaglutide

    Glycine

    Cyanocobalamin (Vitamin B12)

  • HOW TO USE

    Suggested Dosing

    Injections should be administered subcutaneously (under the skin) one time weekly. Dosing typically begins at a lower dose, suggested initiation of 4 units (0.04 mL) weekly for the first 4 weeks, then escalates according to a titration schedule:

    • Weeks 1-4: Inject 4 units (0.04 mL) one time per week
    • Weeks 5-8: Inject 8 units (0.08 mL) one time per week
    • Weeks 9-12: Inject 18 units (0.18 mL) one time per week
    • Weeks 13-16: Inject 30 units (0.3 mL) one time per week
    • Week 16+: Inject 44 units (0.44 mL) one time per week

    Dosing may deviate from this pattern to accommodate patient-specific needs.

  • DISCLAIMER

    This compounded medication is only available when the commercially available product is unavailable or when a prescriber determines that there is a clinically significant difference for the patient.

FIND A PROVIDER

Medicine Information

  • Potential Benefits

    • Decreases appetite and reduces cravings
    • Promotes weight loss2-4
    • Lowers A1C levels (a marker of blood sugar control)
    • Improves cardiometabolic health measures
    • Enhances insulin sensitivity1-3


  • Treatment Protocol

    • The medication is not insulin.
    • Dose adjustments should aim for the lowest appropriate dose to limit side effects and improve adherence.
    • Side effects such as nausea, constipation, acid reflux, stomach pain, vomiting, diarrhea, and injection site reactions are common.
  • Legal

  • Storage Instructions

    Store refrigerated

  • Warnings

    • Contraindicated in patients with a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia Syndromes (MEN 2)
    • Not suitable for individuals with type 1 diabetes or diabetic ketoacidosis
    • Should not be used alongside other GLP-1 receptor medications
    • Gastric emptying may be delayed, requiring caution for procedures involving sedation or general anesthesia due to aspiration risk
    • Use caution in those with a history of diabetic retinopathy1-3
    • Consult your healthcare provider if you have a history of pancreatitis, as the medication may increase risk
    • Serious side effects may involve hypoglycemia, kidney issues, or allergic reactions
    • Avoid use during pregnancy and breastfeeding1
  • Manufacturer Info

  • How It Works

    • Enhances glucose-dependent insulin secretion
    • Suppresses glucagon secretion
    • Slows gastric emptying
    • Influences brain regions involved in appetite regulation, leading to reduced hunger and caloric intake
    • Improves insulin sensitivity1-3
    • Supports weight loss
    • Helps to minimize internal inflammation and improves cardiometabolic health measures5
  • F.A.Q

    Q: How long does it take to see results? 

    A: Benefits like appetite reduction and weight loss may be observed within weeks, but individual responses vary.

    Q: Can I use this with other medications? 

    A: It can be used with other medications, but it should not be used with other GLP-1 medications. Always inform your healthcare provider about all medications you're taking to to address possible interactions.

    Q: Why is it formulated with glycine and vitamin B12?

    A: Cyanocobalamin (vitamin B12) and glycine are added to support side effect management and muscle preservation.

    Q: What if I miss an injection? 

    A: Contact your healthcare provider for guidance on missed doses.

  • References

    IMPORTANT INFORMATION ABOUT COMPOUNDED MEDICATIONS

    This medication has been compounded (custom-prepared) by a pharmacy. Compounded medications are specially prepared for individual patient needs based on a valid prescription and, as such, are not reviewed or approved by the U.S. Food and Drug Administration (FDA) for safety or efficacy. These statements have not been evaluated by the FDA.

    This compounded preparation:

    • Has not been approved by the FDA
    • Has not undergone FDA review for safety, effectiveness, or quality
    • Is prepared specifically for you based on your prescriber's order
    • Individual outcomes may vary

    Dosing is determined by the prescribing provider based on patient-specific factors. Always follow your healthcare provider's instructions. Compounded medications are not subject to FDA approval and lack the same safety and efficacy data as FDA-approved commercial medications. This medication should be prescribed and monitored by a licensed healthcare professional familiar with the condition being addressed and the specific applications of the medication.


    1. Lexicomp Online. Semaglutide: Drug information. Lexi-Drugs database. Wolters Kluwer. Accessed May 14, 2025. https://online.lexi.com/lco/action/ doc/retrieve/docid/patch_f/6577162

    2. Chao AM, Tronieri JS, Amaro A, Wadden TA. Clinical Insight on Semaglutide for Chronic Weight Management in Adults: Patient Selection and Special Considerations. Drug Des Devel Ther. 2022 Dec 29;16:4449-4461. doi: 10.2147/DDDT.S365416. PMID: 36601368; PMCID: PMC9807016.

    3. Khoo TK, Lin J. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Jul 1;385(1):e4. doi: 10.1056/NEJMc2106918. PMID: 34192447.

    4. Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lingvay I, Oral TK, Michelsen MM, Plutzky J, Tornøe CW, Ryan DH; SELECT Trial Investigators. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. N Engl J Med. 2023 Dec 14;389(24):2221-2232. doi: 10.1056/NEJMoa2307563. Epub 2023 Nov 11. PMID: 37952131.

  • Related Articles

    Providers

    /

    6.18.2026

    Men’s Health Optimization Webinar: Testosterone & Personalized Care

    Patients

    /

    6.18.2026

    Defying the Odds: Casey Watson’s Story

    Providers

    /

    6.8.2026

    Beyond Single-Agent Approaches : Vast Compounded Sublingual Formulation for Erectile Wellness

    Providers

    /

    6.5.2026

    Health Is Attainable at Any Age: A Personalized Approach to Men’s Hormone Health

    Providers

    /

    6.1.2026

    BHRT in Women’s Health: What Providers Might Be Missing in Perimenopause and Menopause

    Providers

    /

    6.5.2026

    What Healthcare Gets Wrong About Women’s Hormones with Valerie Richards, PharmD

    Providers

    /

    5.13.2026

    Hair Follicle Support & Scalp Health | Hair Force One

    Providers

    /

    5.4.2026

    Defy Dismissal: Why Women’s Hormone Health Has Been Overlooked

    Providers

    /

    4.28.2026

    How Strive Supports Clinics Delivering Personalized Medicine

    Providers

    /

    3.31.2026

    Lipo Burn: A Practical Approach to Weight Management | Strive Sessions Webinar Recap

    Providers

    /

    3.10.2026

    Setting the Standard in Compounding Webinar Recap | Strive Sessions

    Providers

    /

    3.10.2026

    Lipo Burn: A Clinical Overview for Personalized Weight Management Options

    Providers

    /

    2.24.2026

    Setting the Standard in Compounding: Choosing the Right Partner

    Providers

    /

    6.5.2026

    The Clinical Role of Glutathione: A Webinar Recap for Functional and Integrative Providers

    Providers

    /

    2.16.2026

    Watch the Strive Supplements Webinar: A Clinical Perspective for Providers

    Providers

    /

    1.26.2026

    Glutathione Deep Dive: Clinical Insights for Multisystem Redox and Cellular Health

    Providers

    /

    1.6.2026

    Sermorelin Essentials | Strive Sessions Ep. 5

    General

    /

    1.6.2026

    A Milestone Week at Strive: 1,000 Employees, a New Headquarters, and What Comes Next

    Providers

    /

    12.16.2025

    Elevate-T: A Capsule-Based Approach to Testosterone Optimization and Fertility Preservation

    Providers

    /

    6.16.2026

    Compounded Sermorelin for Clinical Practice: A Practitioner’s Guide

    Providers

    /

    12.10.2025

    Hormone Health Strategies to Support Performance, Peace, and Pleasure | Strive Session Ep. 4

    Providers

    /

    11.17.2025

    Progesterone in Practice: What Every Provider Should Know

    Providers

    /

    11.17.2025

    The Ultimate Insider's Guide to A4M Longevity Fest: 10 Pro Tips

    Patients

    /

    6.5.2026

    What Is a Compounding Pharmacy?

    Providers

    /

    11.21.2025

    Unlocking NAD+ | Strive Sessions Ep. 3

    General

    /

    11.14.2025

    Strive Acquires Pharmaceutical Manufacturing Facility in Alachua, FL

    Providers

    /

    11.14.2025

    NAD⁺ Flex-Dose Tablets: Simple Dosing and Needle-Free Support for Cellular Energy and Repair

    Providers

    /

    11.14.2025

    Tadalafil: A Provider’s Guide to Daily Use, Dosing, and Counseling

    Providers

    /

    10.21.2025

    Master LifeFile: Confident Prescribing Starts Here | Strive Sessions Ep. 2

    Providers

    /

    5.27.2026

    Enclomiphene: Help Restore Testosterone & Fertility in Men

    Providers

    /

    9.22.2025

    Strive Sessions: Redefining Provider Education for Personalized Medicine

    Patients

    /

    9.10.2025

    What Is NAD+? 11 Insights on This Breakthrough Wellness Solution

    Patients

    /

    8.19.2025

    How NMN Supplements Can Help You Feel Younger and Healthier

    Providers

    /

    8.19.2025

    LDN for Weight Management: A Provider's Guide to Personalized Care

    Patients

    /

    5.18.2026

    GLP-1 Meds Slowed Your Digestion? This Can Help.

    Providers

    /

    8.19.2025

    The Science of NAD+: What Providers Need to Know

    Patients

    /

    8.19.2025

    Managing Hashimoto's Symptoms with Low-Dose Naltrexone: Your Guide to Personalized Autoimmune Care

    Patients

    /

    8.19.2025

    Metabolic Refresh: Help Reset Your Metabolism and Reclaim Your Energy

    VIEW ALL ARTICLES

    CART

    Product Title
    $0
    $0
    Option 1 / Option 2 / Option 3
    Subscription Plan Info
    Product Discount (-$0)
    COUPON1 (-$0)
    -
    +

    REMOVE

    Your cart’s empty…  
    Add something awesome!
    Cart note
    Subtotal:
    $0
    COUPON2
    -$0
    Order Discount:
    -$0
    Cart Total:
    $0
    CONTINUE SHOPPING